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ea0026oc3.1 | Bone/Reproduction | ECE2011

Mild hyponatremia as a risk factor for fractures: the Rotterdam study

Hoorn E J , Rivadeneira F , van Meurs J B J , Ziere G , Stricker B H Ch , Hofman Albert , Pols Huibert , Zietse R , Uitterlinden A G , Zillikens M C

Introduction: Recent studies suggest that mild hyponatremia is associated with fractures, but prospective studies are lacking.Aim: Our aim was to study whether hyponatremia is associated with fractures, falls and/or bone mineral density (BMD).Methods: Five thousand two hundred and eight elderly men and women with serum sodium assessed at baseline were included from the prospective, population-based Rotterdam Study. The following da...

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ea0026p517 | Bone/calcium/Vitamin D | ECE2011

Genome-wide association in the Rotterdam study implicates the 16q24 locus as determinant of osteoporotic vertebral fractures

Oei H L D W , Estrada K , Castano-Betancourt M C , van der Klift M , Kerkhof J M , Hofman A , Pols H A P , Stolk L , van Meurs J B , Zillikens M C , Uitterlinden A G , Rivadeneira F

Risk for vertebral fractures (VFx), the most common osteoporotic fractures, is a heritable complex trait. No genome-wide association studies (GWAS) searching for genetic susceptibility factors for VFx have been reported. We performed a GWAS for VFx in a population-based study of Dutch elderly. Thoracolumbar spine radiographs were scored for osteoporotic VFx using the McCloskey/Kanis method. Genetic data was available in 329 VFx cases and 2666 controls. We tested 2 543 887 impu...

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Endocrine Abstracts

Mild hyponatremia as a risk factor for fractures: the Rotterdam study

Genome-wide association in the Rotterdam study implicates the 16q24 locus as determinant of osteoporotic vertebral fractures

BiosciAbstracts